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Ana Figueiras

Professor Ana Rita Figueiras has obtained her Ph.D degree from the University of Coimbra, and is Researcher and Assistant Professor in the Faculty of Pharmacy in this institution. Actually, Ana Figueiras is scientific member of REQUIMTE/LAQV. Her research areas are polymeric micelles, cyclodextrins and mucoadhesive polymers in drug delivery. During her Ph.D. thesis she acquired experience in drug permeability, cellular viability and cytotoxicity studies, mucoadhesive biomaterials, therapeutic applications of cyclodextrins and computational studies in drug design. Now, her objective is to combine know-how development during her Ph.D thesis and new strategies for successful drug delivery, especially in what concerns the use of block copolymers and micellar systems. She has numerous scientific publications in prestigious journals, several book chapters and various communications in international conferences.

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Mixed Polymeric Micelles for Osteosarcoma Therapy: Development and Characterization

Osteosarcoma is a rare bone tumor that has a high incidence amongchildren and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to thepresence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basicscience behind the treatment of osteosarcoma along with experimental resultsfor a novel formulation that overcomes multidrug resistance, and therefore, mayserve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of the disease, while also introducing the readerto new therapies and materials (specifically chitosan, polyethyleneimine, poloxamers,poloxamines, and Pluronics®) used in the treatment process along with the aimsof the experiments present subsequently. Next, the book documents the materialsand methods used in developing polymeric micelles for delivering drugs toosteosarcoma sites. By explaining the basics of nanomedicine as a startingpoint, readers will understand how polymeric micelles act as facilitators ofdrug transport to cancer cells, and how one can synthesize a small stablemicelle (by creating derivatives of base nanomaterials), capable of activelytargeting osteosarcoma cells and overcoming multi-drug resistance. The chapterexplains the synthesis and characterization techniques of the materials used todevelop polymeric micelles.The results, a reflection of the conjugation of different experimentalsolutions initiated here, point to a modern route towards the search for a therapeutic solution for osteosarcoma.The simple, structured presentation coupled with relevant informationon the subject of micelle-based nanotherapeutic drug delivery make thismonograph an essential handbook for pharmaceutical scientists involved in thefield of nanomedicine, drug delivery, cancer therapy and any researchersassisting specialists in clinical oncology for the treatment of osteosarcoma.

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