"This comprehensive compendium unravels the intricacies of three common and daunting skeletal disorders: osteoporosis, osteoarthritis, and rheumatoid arthritis. These ailments afflict people across all age groups, demanding a deeper understanding of their diagnostic, prognostic, preventive, and therapeutic dimensions.
 
 
 
It presents seven key topics written by medical experts that explore research on these diseases:
 
    Chronic Lung Disease and Osteoporosis
        An exploration of the intricate link between chronic lung ailments and osteoporosis.
    AI Detection of Knee Osteoarthritis
        Recent use of artificial intelligence aiding knee osteoarthritis identification.
    Inflammatory Signalling in Rheumatoid Arthritis
        Covers the role of cytokines and chemokines in the context of rheumatoid arthritis.
    Vitamin D, Immune System, and Bone Health
        Unveils the vital implications of Vitamin D on the immune system and bone health.
    Bone Water and Hydration Effects
        A review of the impact of drugs on bone hydration status through the lens of bone water.
    Dietary Patterns and Rheumatoid Arthritis
        An analysis of the connection between dietary habits and rheumatoid arthritis.
    Quality of Life in Rheumatoid Arthritis Patients (Chapters 112-130):
        An examination of the self-perceived quality of life in Rheumatoid Arthritis patients, comparing South Asian and British White populations.
 
 
 
This knowledge-rich treatise is a valuable resource for patients and their families battling these skeletal ailments. It's equally beneficial for medical students, orthopedists, researchers, and anyone eager to grasp the complexities of these widespread skeletal pathologies. "


Osteoporosis, Osteoarthritis and Rheumatoid Arthritis: An Agonizing Skeletal Triad

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GRADING OF KOA: Kellgren and Lawrence Classification and Its Shortcomings

Convolutional Neural Network: Classification Model

Convolutional Neural Network: Object Detection Model

Detection of Knee Osteoarthritis using Artificial Intelligence

Role and Relevance of Cytokines in RA Pathogenesis

Role and Relevance of Chemokines in RA Pathogenesis

Role of Cytokines and Chemokines in Rheumatoid Arthritis

Effects of Vitamin D on Innate Immune System

Effects of Vitamin D on the Adaptive Immune System

TARGETING THE IMMUNOMODULATORY ROLE OF VITAMIN D FOR THE MANAGEMENT OF VARIOUS BONE PATHOLOGIES

Vitamin D and Immune System: Implications in Bone Health

RELATIONSHIP BETWEEN BODY WATER AND BONE WATER

CORRELATION BETWEEN DEHYDRATION AND BONE PATHOLOGIES

Bone Water: Effects of Drugs on Bone Hydration Status

INDIVIDUAL FOOD ITEMS AND THEIR ROLE IN RA

Dietary Patterns and Rheumatoid Arthritis

Self-perceived Quality of Life in South Asian and British White Rheumatoid Arthritis Patients in the East Midlands, UK

Bentham Science Publishers

Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer’s disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mechanisms.
 
 
This book is a review of the scientific findings of distinguished scholars who have studied NLRP3 inflammasome activation and its contribution in worsening the outcomes of inflammatory disorders.
 
 
 
This collection of chapters covers many aspects of the multifaceted role of NLRP3 inflammasome. Beginning with airway inflammation and fibrosis, it progresses to explore its involvement in pulmonary hypertension, heart diseases, tuberculosis, cardiovascular complications, and childhood asthma. Additionally, it examines the inflammasome's impact on protozoan parasitic infections and neuropathic pain. The chapters not only elucidate the intricate mechanisms of NLRP3 activation but also discuss potential inhibitors and therapeutic targets. Readers will gain a comprehensive understanding of the NLRP3 inflammasome's diverse implications across different physiological contexts. The book includes references making this book a valuable treatise of insights for researchers, clinicians, and healthcare professionals.
 
 
 
 
 
Readership
 
Researchers, clinicians, and healthcare professionals.

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Osteoporosis, Osteoarthritis and Rheumatoid Arthritis: An Agonizing Skeletal Triad

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