This book constitutes the refereed post-conference proceedings of 13 workshops held at the 34th International ISC High Performance 2019 Conference, in Frankfurt, Germany, in June 2019: HPC I/O in the Data Center (HPC-IODC), Workshop on Performance & Scalability of Storage Systems (WOPSSS), Workshop on Performance & Scalability of Storage Systems (WOPSSS), 13th Workshop on Virtualization in High-Performance Cloud Computing (VHPC '18), 3rd International Workshop on In Situ Visualization: Introduction and Applications, ExaComm: Fourth International Workshop on Communication Architectures for HPC, Big Data, Deep Learning and Clouds at Extreme Scale, International Workshop on OpenPOWER for HPC (IWOPH18), IXPUG Workshop: Many-core Computing on Intel, Processors: Applications, Performance and Best-Practice Solutions, Workshop on Sustainable Ultrascale Computing Systems, Approximate and Transprecision Computing on Emerging Technologies (ATCET), First Workshop on the Convergence of Large Scale Simulation and Artificial Intelligence, 3rd Workshop for Open Source Supercomputing (OpenSuCo), First Workshop on Interactive High-Performance Computing, Workshop on Performance Portable Programming Models for Accelerators (P^3MA). The 48 full papers included in this volume were carefully reviewed and selected. They cover all aspects of research, development, and application of large-scale, high performance experimental and commercial systems. Topics include HPC computer architecture and hardware; programming models, system software, and applications; solutions for heterogeneity, reliability, power efficiency of systems; virtualization and containerized environments; big data and cloud computing; and artificial intelligence.This book constitutes the refereed post-conference proceedings of 13 workshops held at the 34th International ISC High Performance 2019 Conference, in Frankfurt, Germany, in June 2019: HPC I/O in the Data Center (HPC-IODC), Workshop on Performance & Scalability of Storage Systems (WOPSSS), Workshop on Performance & Scalability of Storage Systems (WOPSSS), 13th Workshop on Virtualization in High-Performance Cloud Computing (VHPC '18), 3rd International Workshop on In Situ Visualization: Introduction and Applications, ExaComm: Fourth International Workshop on Communication Architectures for HPC, Big Data, Deep Learning and Clouds at Extreme Scale, International Workshop on OpenPOWER for HPC (IWOPH18), IXPUG Workshop: Many-core Computing on Intel, Processors: Applications, Performance and Best-Practice Solutions, Workshop on Sustainable Ultrascale Computing Systems, Approximate and Transprecision Computing on Emerging Technologies (ATCET), First Workshop on the Convergence of Large Scale Simulation and Artificial Intelligence, 3rd Workshop for Open Source Supercomputing (OpenSuCo), First Workshop on Interactive High-Performance Computing, Workshop on Performance Portable Programming Models for Accelerators (P^3MA). The 48 full papers included in this volume were carefully reviewed and selected. They cover all aspects of research, development, and application of large-scale, high performance experimental and commercial systems. Topics include HPC computer architecture and hardware; programming models, system software, and applications; solutions for heterogeneity, reliability, power efficiency of systems; virtualization and containerized environments; big data and cloud computing; and artificial intelligence.