H. Scott Baldwin(editor)
Department of Pediatrics and Cell and Developmental Biology,Vanderbilt University Medical Center,Nashville,USA Dr. Baldwin’s research efforts have concentrated on delineating the molecular basis of vascular development in the mammalian embryo as an approach to understanding the etiology of congenital heart diseases. His laboratory efforts are based on the hypothesis that the developing vasculature provides important patterning information that directs subsequent cardiac and pulmonary morphogenetic events. Investigations have focused on two areas: 1) the role of endothelial cell adhesion molecules, particularly PECAM-1, in regulating vascular ontogeny and 2) the role of NFATc-1 in specification of endocardial development during early organogenesis. Department of Pediatrics and Cell and Developmental Biology,Vanderbilt University Medical Center,Nashville,USA Dr. Baldwin’s research efforts have concentrated on delineating the molecular basis of vascular development in the mammalian embryo as an approach to understanding the etiology of congenital heart diseases. His laboratory efforts are based on the hypothesis that the developing vasculature provides important patterning information that directs subsequent cardiac and pulmonary morphogenetic events. Investigations have focused on two areas: 1) the role of endothelial cell adhesion molecules, particularly PECAM-1, in regulating vascular ontogeny and 2) the role of NFATc-1 in specification of endocardial development during early organogenesis.
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Department of Pediatrics and Cell and Developmental Biology,Vanderbilt University Medical Center,Nashville,USA Dr. Baldwin’s research efforts have concentrated on delineating the molecular basis of vascular development in the mammalian embryo as an approach to understanding the etiology of congenital heart diseases. His laboratory efforts are based on the hypothesis that the developing vasculature provides important patterning information that directs subsequent cardiac and pulmonary morphogenetic events. Investigations have focused on two areas: 1) the role of endothelial cell adhesion molecules, particularly PECAM-1, in regulating vascular ontogeny and 2) the role of NFATc-1 in specification of endocardial development during early organogenesis.
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Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
