"
COVID-19: Epidemiology, Biochemistry, and Diagnostics explains COVID-19 from multidisciplinary angles such as the evolution of SARS-COV, genetic techniques to study the virus, and diagnostic methodologies widely used in the global COVID-19 pandemic.
 
The chapters in this book provide the reader with up-to-date literature about research on SARS-CoV-2 through three parts:
 
I) Evolution and Entry of SARS-CoV-2 into the host
 
II) Genetic Alteration and Structural Determination of SARS-CoV-2 Proteins
 
III) Quantitative Analysis of SARS-CoV-2 for research and medical diagnosis
 
 
Key Features:
 
- 15 chapters on SAR-CoV-2 in a multidisciplinary context
 
- Provides a comprehensive overview of SARS-CoV-2 evolution and genetics
 
- Provides biochemical information about SARS-CoV-2 proteins and receptor targets (both structural and non-structural proteins)
 
- Includes an overview of several methods of detecting SARS-CoV-2 virus particles (ELISA, PCR, Neutralizing Antibodies
 
- Covers some critical diagnostic modalities for COVID-19 diagnosis
 
- Provides bibliographic references for further reading
 
 
Readers will understand the significance of phylogenetic analysis of coronaviruses, along with the pathogenesis of COVID-19 and related diseases such as SARS and MERS. Applications of biochemical technologies such as RT-PCR and CRISPR are also demonstrated in the text. This book is a comprehensive introduction to COVID-19 research for medical researchers, microbiologists and virologists. Students in academic programs in life sciences and medicine will also benefit from the information provided in the book."


COVID-19: Epidemiology, Biochemistry, and Diagnostics

Bentham Science Publishers

Kamal Niaz

Muhammad Farrukh Nisar

"With the emergence of new coronavirus variants, epidemiology, host tropism presents an opportunity for a thorough analysis of their evolution and acquired adaptability to their host. These studies require different animal models and treatment approaches. No studies are complete without animal models closely related to human physiology to replicate the disease and observe the pathological conditions for comparison to human cases. Such animal models play a vital role in virus pathogenesis and prepare a therapeutic immune response in the organism studied.
 
This volume focuses on two aspects of COVID-19 infection: Models for SARS-CoV-2 infection and Treatment Strategies for SARS-CoV-2 infection, respectively. Chapters in the first part describe bio-engineered transgenic mouse models with specific genes (including models created with CRISPR-Cas9 gene editing tools used previously for SARS-CoV and MERS-CoV), cell culture lines for COVID-19 studies and the histopathology of COVID-19. The section also includes a chapter covering essential proteins that up or down-regulate SARS-CoV-2 multiplication. The last chapter of this part describes other diseases having similar signs and symptoms and their differential diagnosis. The next section covers different treatment strategies for COVID-19. There is no specific treatment available to date, just symptomatic therapy. However, scientists have been testing antiviral drugs in clinical trials, phytochemicals, photomedicine such as UV A & B light, homemade remedies, blood plasma transfusion, stem cell therapy, and computational approaches in both in vivo and in vitro trials. This book serves as an ideal resource on these aspects of COVID-19 for academicians, scientists, and health professionals. "


Coronavirus Disease-19 (COVID-19): Different Models and Treatment Strategies

Genetic Diversity of Coronaviruses (Volume 1) provides a comprehensive analysis of the genetic mutations and host interactions across three major coronaviruses—SARS-CoV, MERS-CoV, and SARS-CoV-2. This volume explores the evolutionary history, mutations, and emerging variants of these viruses, with a focus on understanding how they adapt to different hosts. The book is organized into three parts: Part I covers SARS-CoV, detailing its genetic mutations, host genetic diversity, and new variants. Part II focuses on MERS-CoV, offering insights into mutations and host adaptations. Part III addresses SARS-CoV-2, discussing its evolving variants and the role of host proteins. The book also discusses the connections between coronaviruses and neurological, epigenetic, and AI-related issues.
 
 
Key Features:
- In-depth analysis of genetic mutations in coronaviruses.
- Exploration of host genetic diversity and virus adaptation.
- Insight into emerging variants of SARS-CoV, MERS-CoV, and SARS-CoV-2.
- Examination of host proteins' role in viral infections.
- Discussion on the impact of AI and epigenetics on coronavirus research.
 
Readership: College students, researchers, scientists, and health professionals.

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